IBS Explained: What Your Gut’s Trying to Tell You
- Dr. Nazanin Safaei, ND, MS
- Jun 27
- 5 min read
Updated: Jul 10

Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder that affects millions of people worldwide. Characterized by abdominal pain, bloating, and changes in bowel habits, IBS can significantly impact quality of life. Despite its prevalence, many individuals go undiagnosed or misinterpret their symptoms. This guide covers the signs, causes, and treatment options for IBS to help you better understand this common condition and seek proper care.
What Is IBS?
IBS is a disorder of the gut-brain axis, meaning it involves both the gastrointestinal system and the nervous system. Unlike inflammatory bowel diseases (IBD) such as Crohn’s disease or ulcerative colitis, IBS does not cause severe inflammation or significant damage to the intestines. However, it can be just as disruptive, and if left untreated lead to broader health issues.
There are three main types of IBS:
IBS-D: Predominantly diarrhea
IBS-C: Predominantly constipation
IBS-M: Mixed, with both constipation and diarrhea
Common Signs and Symptoms of IBS
The symptoms of IBS vary but generally include:
Abdominal pain or cramping (often relieved by bowel movements)
Bloating and gas
Diarrhea, constipation, or alternating between both
Mucus in the stool
A sensation of incomplete evacuation
Symptoms may be triggered or worsened by stress, specific foods, hormonal changes, or illness. They tend to occur repeatedly over time rather than being constant.
Causes and Risk Factors
Several factors appear to play a role:
Gut-brain interaction: Abnormal communication between the brain and gut due to neurotransmitter imbalances can affect motility, sensation, immune function, and mood regulation - all key factors in IBS pathophysiology.
Changes in gut microbiota: Imbalances in intestinal bacteria may contribute to symptoms. It is estimated that up to 78% of patients with IBS suffer from SIBO, a condition caused by bacterial overgrowth in the small intestine.
Food sensitivities: Some individuals have exaggerated digestive responses to specific foods, such as gluten or dairy.
Stress and anxiety: Psychological stress is strongly linked to IBS flare-ups. Sympathetic dominance, where the sympathetic nervous system (SNS)—the “fight or flight” arm of the nervous system—is overly active relative to the parasympathetic (“rest and digest”) system can contribute to the IBS symptoms, especially due to its influence on gut motility, sensitivity, and secretion.
Gastrointestinal infections: Some cases of IBS begin after a severe bout of gastroenteritis (post-infectious IBS) or due to overgrowth of yeast in the bowels.
Inadequate Digestion: enzyme and stomach acid deficiencies, and improper bile acid reabsorption can result in IBS symptoms.
Genetics and early life experiences (like trauma or abuse) may also increase susceptibility.
Diagnosis
Diagnosis typically involves assessing symptoms and ruling out other conditions like celiac disease, IBD, and colon cancer. Rome IV criteria is used to aid in the diagnosis based on symptoms; according to this criteria IBS is diagnosed when recurrent abdominal pain is present for at least one day per week in three months, related to bowel movements or associated with changes in frequency or form (appearance) of stools. Certain specialty tests such as IBS-Smart measuring anti-CdtB and anti-vinculin antibodies, may also be utilized to aid in the diagnosis of post-infectious IBS.
Treatment Options for IBS
Conventional approaches often focus on symptom management through dietary changes, like a low FODMAP diet, and medications such as antispasmodics, laxatives, antidiarrheal agents, or antidepressants. Naturopathic medicine, however, aims to identify and treat the underlying causes of IBS. In my clinical practice, I often reserve restrictive dietary interventions and medications for cases of resistant IBS not responsive to other targeted treatments.
Daily digestive care discussed in my post: "Your Daily Digest: Simple Tips for a Healthier Gut", can be a great adjunct to any targeted treatments.
Final Thoughts
If you experience persistent digestive symptoms that interfere with daily life, it’s important to seek medical advice. With the right treatment plan, most people with IBS can recover from the symptoms or see significant improvements, leading to more comfortable and active lives.
Disclaimer: The information provided in this article is for informational and educational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making changes to your diet, lifestyle, or health care regimen.
References
Camilleri M. Management of the irritable bowel syndrome. Gastroenterology. 2001;120(3):652-668.
Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome: a clinical review. JAMA. 2015;313(9):949-958.
Ford AC, Lacy BE, Talley NJ. Irritable bowel syndrome. N Engl J Med. 2017;376(26):2566-2578.
Staudacher HM, Whelan K. The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS. Gut. 2017;66(8):1517-1527.
Drossman DA, Hasler WL. Rome IV—functional GI disorders: disorders of gut-brain interaction. Gastroenterology. 2016;150(6):1257-1261.
Lacy BE, Pimentel M, Brenner DM, et al. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. Am J Gastroenterol. 2021;116(1):17-44.
Ghoshal UC, Srivastava D. Irritable bowel syndrome and small intestinal bacterial overgrowth: Meaningful association or unnecessary hype. World J Gastroenterol. 2014;20(10):2482–2491
Pimentel M, Saad RJ, Long MD, Rao SSC. ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. Am J Gastroenterol. 2020;115(2):165-178.
Santelmann H, Howard JM. Yeast metabolic products, yeast antigens and yeasts as possible triggers for irritable bowel syndrome. Eur J Gastroenterol Hepatol. 2005;17(1):21–26.
Camilleri M. Bile acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver. 2015;9(3):332–339.
Di Stefano M, Miceli E, Mazzocchi S, Tana P, Corazza GR. Fat malabsorption and irritable bowel syndrome-like symptoms: a new and common presentation of exocrine pancreatic insufficiency. J Clin Gastroenterol. 2007;41(7):613–617.
Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol. 2005;96(2):94–102.
Shepherd SJ, Parker FC, Muir JG, Gibson PR. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol. 2008;6(7):765–771.
Rome Foundation. Rome IV Diagnostic Criteria. Rome Foundation. Updated 2016. Accessed June 23, 2025. https://theromefoundation.org/rome-iv/rome-iv-criteria/
IBS‑Smart. The Untold Story of IBS: Post‑Infectious Irritable Bowel Syndrome. IBS‑Smart. Published [n.d.]. Accessed June 24, 2025. https://www.ibssmart.com/post-infectious-ibs Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007;132(1):397–414.
Camilleri M. Serotonin in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes. 2009;16(1):53–59.
O'Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015;277:32–48.
Midenfjord I, Tornblom H, Simren M. Gut-directed hypnotherapy improves symptoms in patients with irritable bowel syndrome and high levels of neuroticism. Neurogastroenterol Motil. 2019;31(2):e13513.
Husebye E, Hellström PM, Midtvedt T. Intestinal microflora, neuropeptides and motility. Neurogastroenterol Motil. 2001;13(5):387–396.
Mayer EA, Labus JS, Tillisch K, Cole SW, Baldi P. Towards a systems view of IBS. Nat Rev Gastroenterol Hepatol. 2015;12(10):592–605.
©2025 by Nazanin Safaei, ND, MS